The prehistoric settlements, which came in the light in the boundaries of modern city of Larissa, testify a habitation until the Ancient Neolithic Era (6.000 - 5.800 B.C.). Based in discoveries that were found in the wider region of Thessaly by archaeologist V. Milojcic, this wider time period is subdivided in [Protosesklo] (5.500 B.C.), [Sesklo] II - phase of ancient Neolithic (Protosesklo), Vorsesesklo and Sesklo Kultur.
It is remarkable to be mentioned that wider region of modern city of Larissa is one among few, in the Hellenic space, that they were inhabited, in that extent and continuously, until the 6th millennium.
The most characteristic therefore places of inhabitation which are in the boundaries of Municipality of Larissa are the following:
1. At the hill of Saint Achillean
2. Location in the Karditsis Road.
3. Location in the former Motel Xenia – nowadays the location at Grecotel Imperial
4. Location "Vrastiras" near the national road, in the position of Travel Stop, in the height between the roads Gorgopotamou and Theopetras.
Given the fact of the relatively small space which prehistoric settlements were extended, that is to say, of a certain space of tens of acres, it’s justified the number of four different places that were mentioned above, in the boundaries of city and other three prehistoric settlements which are located in the space of the military airport of Larissa.
Concerning excavations of prehistoric settlements in the Prefecture Larissa that were carried out during big public constructions until 1990, (near Mandra, Rahmani, Makrixori, Platykampos and Dimitra villages), many new data were collected on the land- planning of settlements, the cultural aspects and the life of residents in this distant period.
During Neolithic Era (6700 - 3300 B.C.), settlements were often surrounded by yards or ditches which protected the households of prehistoric farmers. Most of the houses were small and were constituted by a room or huts with slightly probing flooring. Walls were constructed mainly by sun- dried bricks, sometimes built on a low level foundation by stones, by a wooden frame of stakes and by a greasing of mortar, while the roof was coated with thick layer of mortar or it was made by grass. The household effects of Neolithic houses included objects for the storage and the cooking of food (hearths, ovens), vessels, and tools by stone or by animals’ bones, also objects for producing textiles as wells as statuettes or favourite personal objects e.g. jewels.
During Copper Era (3300 - 1100 B.C.) while the construction techniques of houses remained, at least in their early phases, almost the same, however some differentiations are observed in the ground plans of houses and in the land- planning of settlements, and this can be perceived as an emanation of the different social organisation. The houses of Main Era of Copper (1900 – 1550 B.C.) in Dimitra village were big, vaulted and elongated (this is the architectural type of "palace") and they were built the one close to other. Among the very little remains of domestic architecture of Later Era of Copper in Prefecture of Larissa, it came to light the ground plan of a house in the Makrixori village with three rooms. Unfortunately, the excavation of this house was never completed.